PtdIns(3,4,5)P3-Dependent and -Independent Roles for PTEN in the Control of Cell Migration
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منابع مشابه
PtdIns(3,4,5)P3-Dependent and -Independent Roles for PTEN in the Control of Cell Migration
BACKGROUND Phosphatase and tensin homolog (PTEN) mediates many of its effects on proliferation, growth, survival, and migration through its PtdIns(3,4,5)P(3) lipid phosphatase activity, suppressing phosphoinositide 3-kinase (PI3K)-dependent signaling pathways. PTEN also possesses a protein phosphatase activity, the role of which is less well characterized. RESULTS We have investigated the rol...
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ژورنال
عنوان ژورنال: Current Biology
سال: 2007
ISSN: 0960-9822
DOI: 10.1016/j.cub.2006.12.026